Dr. Borhan Uddin Professor, Department of Biochemistry & Molecular Biology
PROFILE
SHORT BIOGRAPHY
I have been serving as a faculty member in the Department of Biochemistry and Molecular Biology at Jahangirnagar University since 2008. I have built a solid foundation in different areas of Cell and Molecular Biology, and thus far, my results have been exemplary. I secured the first position in both undergraduate and graduate examinations at Jahangirnagar University. Additionally, I received a very good grade of 8.5 on the scale of 10 during my second master’s in Molecular life sciences at Wageningen University, The Netherlands. During this research-intense MSc study, I conducted my MSc thesis on Arabidopsis embryogenesis (36 ECTS, January to June 2013) under the supervision of Professor Dr. Dolf Weijers, Laboratory of Biochemistry. The creative environment of Professor Weijers’s lab changed my perspective on recent advancements in molecular biology and provided me with a great opportunity to learn advanced molecular biology and imaging techniques. To fulfill my MSc degree, I completed an internship under the supervision of Professor Dr. Jan Lohmann, Dept. of Stem cell Biology, Center for Organismal Studies (COS), Heidelberg University, Germany (36 ECTS, July 2013 to January 2014).
After completing my MSc study at Wageningen University, I pursued my doctoral study under the supervision of Professor Dr. Elmar Schiebel at the Center for Molecular Biology (ZMBH), Heidelberg University (August 2014 to October 2018). All my research efforts were directed towards deciphering the molecular mechanisms of human CDC14s functions by investigating the knockout cellular models (CRISPR-Cas9) through various imaging and proteomics approaches. I trained myself in various cell and molecular biology techniques such as mammalian cell culture, flow cytometry, confocal microscopy, mass spectrometry, immunohistochemistry, genetic engineering, etc. I believe that the rigorous training in Professor Schiebel’s lab has transformed me into an independent researcher capable of solving scientific questions in a structured manner. I had very short stints of post-doctoral research in Professor Dr. David Stephens’s lab at the University of Bristol, UK (July 2019 to December 2019) and in Professor Dr. Irfan Lodhi’s lab at Washington University in St Louis, USA (August 2021 to October 2021).
My research interests include cancer biology, cell signaling, molecular genetics, and Genomics & Bioinformatics. Honestly speaking, I really love science. Even the simplest appearance of a gel band from PCR or Western Blot still makes me happy!
ORCID ID: https://orcid.org/0000-0001-9142-7568
UK Cilia Network: https://www.cilianetwork.org.uk/people/buddin
Google Scholar: https://scholar.google.com/citations?user=I3mGbcYAAAAJ&hl=en&authuser=2
- Web of Science ResearcherID: U-9562-2019
- Web Of Science
- Scopus: https://www.scopus.com/authid/detail.uri?authorId=6507956903
RESEARCH INTEREST
Cell and Molecular Biology, Complementary and Alternative Medicine
JOURNAL PAPER
https://jcmimagescasereports.org/article/JCM-V4-1606.pdf
Rahman MA, Debnath H, Nahar T, Uddin B, Alam S, Dutta H, Joy SI, Baraik A, Hossain S. (2024). Evaluation of the effect of brown rice and white rice on protein-energy malnutrition rat models. J Clin Med Img Case Rep. 4(1): 1606.
Journal of Pharmacology and Clinical Toxicology,Alam S, Dutta H, Debnath H, Azmain P, Joy SI, Nahar T, Uddin B, Rahman MA, Hossain S. (2023) Egg Yolk Feeding Induces Hyperlipidemia with a Concomitant Increase in Oxidative Stress in Liver Tissue and Erythrocyte Susceptibility to Hemolysis in Rats. J Pharmacol Clin Toxicol 11(2):1177.
Journal of Cell Science, 2023. doi: https://doi.org/10.1242/jcs.260073
Caroline Shak, Laura Vuolo, Borhan Uddin, Yohei Katoh, Tom Brown, Aakash G. Mukhopadhyay, Kate Heesom, Anthony J. Roberts, Nicola Stevenson, Kazuhisa Nakayama, David J. Stephens, Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2, J Cell Sci (2023) 136 (5): jcs260073.
bioRxiv, 2022. doi: 10.1101/2022.03.31.486414Caroline Shak, Laura Vuolo, Borhan Uddin, Yohei Katoh, Tom Brown, Kate Heesom, Nicola Stevenson, Kazuhisa Nakayama, David Stephens (2022). Clinical mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.
Advances in Traditional Medicine, 2021. doi: https://doi.org/10.1007/s13596-021-00606-2
Bhowmick, S., Sarkar, M., Hussain, J., Hassan, M., Basunia, M., Nahar, T., Rahman, A., Uddin, B., & Hossain, S. (2021). Curcuma longa extract ameliorates motor and cognitive deficits of 6-hydroxydopamine-infused Parkinson’s disease model rats. Advances in Traditional Medicine.
Journal of Cell Science, 2021. doi: https://doi.org/10.1242/jcs.255950Partscht, P, Uddin, B., Schiebel, E (2021). Human cells lacking CDC14A and CDC14B show differences in S phase entry but not in mitotic progression. Article Link
African Journal of Biological Sciences, 3, 1, pp.120 - 128, 2021. doi: https://doi.org/10.33472/AFJBS.3.1.2021.120-128
Shahdat Hossain, Marzan Sarkar, Sujan Bhowmick, Jakir Hussain, Mahmudul Hasan, Borhan Uddin, and Md. Asaduzzaman Khan (2021) Acute cigarette smoke exposure induces oxidative damage and inflammation in Wistar rat: impact on lung and erythrocytes. PDF link
Legume Science,
Hossain, S., Ahmed, R., Bhowmick, S., Sarkar, M., Nahar, T., Uddin, B., Basunia, M., Mamun, A., Hashimoto, M., Shido, S.. (2020) Lablab purpureus (L) bean flour ameliorates plasma proteins and accretion of docosahexaenoic acid (DHA, 22:6, ω‐3) in the plasma, liver, and brain of malnourished rats. Legume Science. 2020; 1– 13. https://doi.org/10.1002/leg3.34
EMBO Reports,
Uddin, B., Partscht, P. Chen, N.P., Neuner, A., Weiß, M., Hardt, R., Pour, A.J., Heßling, B., Ruppert, T., Lorenz, H., Pereira, G., and Schiebel, E. (2019). hCDC14A phosphatase modulates primary cilium length through regulation of actin-dependent processes. EMBO reports, 20(1), ee46544. doi:10.15252/embr.201846544.
PNAS,
Chen, N.P., Uddin, B., Hardt, R., Ding, W., Panic, M., Lucibello, I., Kammerer, P., Ruppert, T., and Schiebel, E. (2017). Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm. Proc. Natl. Acad. Sci. 114, 5201 – 5206.
PNAS,
Chen, N.P., Uddin, B., Voit, R., and Schiebel, E. (2016). Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion. Proc. Natl. Acad. Sci. 113, 990–995.
Plant Reproduction,
Wendrich, J.R., Möller, B.K., Uddin, B., Radoeva, T., Lokerse, A.S., De Rybel, B., and Weijers, D. (2015). A set of domain-specific markers in the Arabidopsis embryo. Plant Reprod. 28: 153-160.
BMC Genomics,
Uddin, B., Chen, N.P., Panic, M., and Schiebel, E. (2015). Genome editing through large insertion leads to the skipping of targeted exon. BMC Genomics 16, 1082.
Journal of Complementary and Integrative Medicine,
Nahar, T., Uddin, B., Hossain, S., Sikder, A. M. and Ahmed, S. (2013). Aloe vera gel protects liver from oxidative stress-induced damage in experimental rat model. J. Complement. Integr. Med. 10, 1.
Adv. Biosci. Biotechnol.,Ahmed, S., Hossain, M.I., Hossan, T., Islam, K.M.R., Uddin, B., Rahman, M.B., and Hossain, M.A. (2013). The Central Cattle Breeding and Dairy Farm, Bangladesh waste contributes in emergence and spread of aminoglycoside-resistant bacteria. Adv. Biosci. Biotechnol. 4, 278–282.
International Journal of Environmental Research and Public Health,Chowdhury, M.A.Z., Banik, S., Uddin, B., Moniruzzaman, M., Karim, N., and Gan, S.H. (2012). Organophosphorus and Carbamate Pesticide Residues Detected in Water Samples Collected from Paddy and Vegetable Fields of the Savar and Dhamrai Upazilas in Bangladesh. Int. J. Environ. Res. Public Health 9, 3318–3329.
Oriental Pharmacy and Experimental medicine,Hossain, S., Rahaman, A., Nahar, T., Basunia, M.A., Mowsumi, F.R., Uddin, B., Shahriar, M., Mahmud, I. (2012). Syzygium cumini (L.) skeels seed extract ameliorates in vitro and in vivo oxidative potentials of the brain cerebral cortex of alcohol-treated rats: Syzygium cumini (L.) skeels seed extract inhibits oxidative potentials of brain. Orient. Pharm. Exp. Med. 12, 59–66.
Journal of Complementary and Integrative Medicine,Hossain. S., Hasan, I., Basunia, M.A., Nahar, T., Rahaman. A., Chowdhury, B.K., Chowdhudry, S.K., Mahmud, I., and Uddin, B. (2011). Syzygium cumini seed extract protects the liver against lipid peroxidation with concurrent amelioration of hepatic enzymes and lipid profile of alcoholic rats, Journal of Complementary and Integrative Medicine; 8(1): 1-17.
CONFERENCE PAPER
ASCB EMBO 2019, doi: https://doi.org/10.1091/mbc.E19-11-06171. Patrick Partscht, Borhan Uddin, Elmar Schiebel. The human phosphatases CDC14A and CDC14B
affect cell cycle progression through their impact on ciliogenesis. ASCB EMBO 2019 meeting, December 7 – 11, 2019. Washington, DC, USA (Poster no 1122).
BOOK
Borhan Uddin, Patrick Partscht, Taslima Nahar, CRISPR-Cas Methods, 2020. doi: https://doi.org/10.1007/978-1-0716-0616-2_9Uddin B., Partscht P., Nahar T. (2020) Genome Editing of Mammalian Cells Using CRISPR-Cas: From In Silico Designing to In-Culture Validation. In: Islam M., Bhowmik P., Molla K. (eds) CRISPR-Cas Methods. Springer Protocols Handbooks. Humana, New York, NY
PhD thesis (2018, Heidelberg University),Linking dephosphorylation to cellular events: Functional analysis of human CDC14 (hCDC14) phosphatases
Teaching
| Course Code | Course Title | Semester/Year |
|---|---|---|
| BMB 501 | Advanced Cell Biology | Masters |
| BGE 504 | Systems Biology | Masters |
| BMB 402 | Genomics, Proteomics, and Bioinformatics | Fourth Year |
| BGE 401 | Genomics and Proteomics | Fourth Year |
| BMB 301 | Cell Biology | Third Year |
| Pharm 3110 | Pathology | Third Year |
| BMB 205 | Human Physiology I | Second Year |
| BMB 1102 | Introductory Molecular Biology | First Year (First Semester) |
Academic Info
Period: February 2014 to February 2018
Ph.D. in Cell and Molecular Biology (ZMBH)
Period: February 2012 to January 2014
MSc in Molecular Life Sciences
Period: 2003 to 2004 (Exam held in 2007)
MS in Biochemistry and Molecular Biology
Period: 1999 to 2003 (Exam held in 2006)
BSc in Biochemistry and Molecular Biology
Period: May 2020 May 2021
Completed MOOC courses from Coursera (During COVID-19 lockdown time; 2020):
- COVID-19 Contact Tracing (Johns Hopkins University)
- Programming for Everybody (Getting Started with Python) - University of Michigan
- Experimental Methods in Systems Biology (Icahn School of Medicine at Mount Sinai)
- The Data Scientist’s Toolbox (Johns Hopkins University)
- Technical Support Fundamentals (Google)
- Data Management and Visualization (Wesleyan University)
- Python Data Structures (University of Michigan)
- Data Analysis Tools (Wesleyan University)
- The Bits and Bytes of Computer Networking (Google)
- Using Python to Access Web Data (University of Michigan)
- AI For Everyone (DeepLearning.AI)
- Introduction to Systems Biology
Experience
Position: Professor
Period: June 2023 - To date
Position: Associate Professor
Period: April 2019 to June 2023
Position: Postdoctoral Research Associate
Period: August 2021 - October 2021
Washington University in St. Louis (School of Medicine, Lodhi Lab)
Position: Research Associate
Period: July 2019 - December 2019
Position: Assistant Professor
Period: November 2011 to April 2019
Position: Lecturer
Period: August 2008 to November 2011
Activity
Position: Elected Member (Teacher's representative)
Period: 2023 -
Position: Joint-Secretary
Period: January 2023 to December 2023
Position: Student Advisor
Period: November 17, 2020 to November 16, 2022
Position: Joint-Secretary
Period: January 2020 - December 2021
Position: Elected Syndicate member in Lecturer Category (According to JU act 1973 22(1)e(vi))
Period: June 2010 to November 2011
Position: Student Advisor
Period: October 2009 to September 2011
Contact
Dr. Borhan Uddin
Professor
Department of Biochemistry & Molecular Biology
Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Cell Phone: +8801707078549
Email: borhan-bmb@juniv.edu
, borhan.masud@gmail.com
