Dr. Tapan Kumar Saha Professor, Department of Chemistry
PROFILE
SHORT BIOGRAPHY
Dr. Tapan Kumar Saha was born in 1966 at Ichakhali, P/S: Kaliganj, District: Jhenaidah. He earned B.Sc. (Honours) in Chemistry (1987; Examination held in 1989) and M.Sc. in Chemistry (1988; Examination held in 1990-91) from Jahangirnagar University, Bangladesh. He obtained his Ph.D. degree in Biopharmaceutical Science under the supervision of Prof. Keietsu Tamagake, Okayama University, Okayama, Japan (March 2002).
Dr. Saha served as a Chemist at Kurita Water Industries Ltd. (Japanese), Dhaka, Bangladesh (February 1992 – June 1992), and as a Scientific Officer, Bangladesh Atomic Energy Commission (September 1992 – May 1993). He joined Jahangirnagar University as a Lecturer in Chemistry in May 1993 and was promoted to the post of Assistant Professor in June 1996; Associate Professor in January 2003 and Professor in September 2007.
Dr. Saha did several Post-doctoral research with (i) Prof. Dr. Hiromu Sakurai, Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan; (ii) Prof. Dr. Debbie C. Crans, Department of Chemistry, Colorado State University, Fort Collins, USA; (iii) Prof. Dr. Franc Meyer, Institute of Inorganic Chemistry, Georg-August-University, Göttingen, Germany. He served as a visiting research fellow (April 1995 – March 1996) with Prof. Dr. Yoshinobu Fukumori, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan.
Dr. Saha received several fellowships/scholarships including (i) Georg Forster Experienced Research Fellowship (Alexander von Humboldt Foundation), Germany, 2010, 2011, 2012, 2019; (ii) Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship, Japan, 2004 – 2006; (iii) Monbusho Scholarship from the Ministry of Education, Culture, Sports, Science and Technology, Japan, 1997 – 2002; (iv) Visiting Research Fellowship from Kobe Gakuin University, Kobe, Japan, 1995 – 1996; (v) Jahangirnagar University Merit Scholarship as B.Sc.(Honours) and Master Degrees student, July 1985 – January 1991.
Dr. Saha is doing collaborative research with (i) Prof. Dr. Franc Meyer, Georg-August-University, Göttingen, Germany; (ii) Prof. Dr. Hiroyuki Yasui, Kyoto Pharmaceutical University, Kyoto, Japan; (iii) Prof. Dr. Hideki Ichikawa, Kobe Gakuin University, Kobe, Japan. His research interests concern the area of Physical, Biophysical, and Bioinorganic Chemistry, and Environmental Chemistry. He invented 2 patents and published 66 research articles in reputed scientific journals at home and abroad. One article was selected as an Awarded Article in the Bulletin of the Chemical Society of Japan, 2006, 79(8), 1191-1200 (https://doi.org/10.1246/bcsj.79.1191).
Dr. Saha received Bangladesh University Grants Commission (UGC) Award 2013 in Physical Science Section (29 March 2015). Recently, he received an equipment subsidy grant from the Alexander von Humboldt (AvH) Foundation in Germany. Dr. Saha served as a Principal Investigator (PI) of several projects received from the Ministry of Education and the Ministry of Science and Technology, Government of the People’s Republic of Bangladesh; University Grants Commission of Bangladesh; Jahangirnagar University.
Dr. Saha is a member of the editorial board of the Journal of Bangladesh Chemical Society (JBCS). He is also a member of various professional societies: (i) Bangladesh Chemical Society (BCS); (ii) Bangladesh Association for the Advancement of Science (BAAS); (iii) Japanese Universities Alumni Association in Bangladesh (JUAAB); (iv) Bangladesh JSPS Alumni Association (BJSPSAA); (v) Association of Humboldt Fellows Bangladesh (AHFB); (vi) Alumni Association of the German Universities in Bangladesh (AAGUB); (vii) Jahangirnagar University Alumni Association (JUAA).
Dr. Saha served as a Founder Provost (April 2014 – April 2018), Bangamata Begum Fazilatunnessa Mujib Hall, Jahangirnagar University; as a Proctor (January 2012 – October 2012 and March 2014 – March 2018), Jahangirnagar University; as an Additional Director (January 2015 – February 2019) Institutional Quality Assurance Cell (IQAC), Jahangirnagar University; as a Provost (March 2009 – January 2012), Jahanara Imam Hall, Jahangirnagar University; as an Executive Member (elected), Jahangirnagar University Teachers' Association (JUTA) (January – December 2011); as an Organizing Secretary, Bangladesh Chemical Congress 2010 (33rd Annual Conference of Bangladesh Chemical Society, Dhaka, Bangladesh), 10 – 12 December 2010. He is serving as a Member of the Senate (elected), Jahangirnagar University (October 2016 – To date).
RESEARCH INTEREST
Syntheses, Characterizations, Catalysis, Kinetics, Adsorption, Modeling, Rapid-scan Stopped-flow Spectrophotometry, Metal- and Metalloporphyrin-Doped Polymer Conjugates, Catalytic and Biological Activities of Conjugates, Analysis of Substrate Degradation Products.
JOURNAL PAPER
Published Papers in Peer-Reviewed Journals (* Corresponding Author)
[67] Chironjit Kumar Shaha, Bithy Sarker, Shurid Kishore Mahalanobish, Md. Sharif Hossain, Subarna Karmaker,* and Tapan Kumar Saha*, Kinetics, Equilibrium, and Thermodynamics for Conjugation of Chitosan with Insulin-Mimetic [mesoTetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4-) in Aqueous Solution, ACS Omega 2023 (Published) https://doi.org/10.1021/acsomega.3c05804
[66] Iffat Ara Shaon, Subarna Karmaker* and Tapan Kumar Saha*, Spectrophotometric Investigation of Oxovanadium(IV)-Ciprofloxacin Complex in Pure and Mixed Solvents. J. Bangladesh Chem. Soc., 2022, 34, 68-73.
[65] Soma Saha, Tapan Kumar Saha*, Subarna Karmaker, Zinia Islam, Serhiy Demeshko, Holm Frauendorf, and Franc Meyer*, Solar Light-Assisted Oxidative Degradation of Ciprofloxacin in Aqueous Solution by Iron(ӀӀӀ) Chelated Cross-linked Chitosan Immobilized on a Glass Plate. Catalysts, 2022, 12, 475. https://doi.org/10.3390/catal12050475.
[64] Pollob Ghosh, Soma Saha, Raton Kumar Bishwas, Subarna Karmaker, and Tapan Kumar Saha*, Adsorption of Amaranth onto Natural Peanut Husk and Cationic Surfactant-Modified Peanut Husk in Aqueous Solution: Kinetic, Isotherm, and Thermodynamic Analysis, Cellulose Chem. Technol., 2022, 56, 443-460. https://doi.org/10.35812/CelluloseChemTechnol.2022.56.38
[63] Subir Chowdhury, Pollob Ghosh, Md. Tuhinur R. Joy, Subarna Karmaker and Tapan Kumar Saha*, Adsorption Characteristics of Amaranth onto Cetyltrimethylammonium Bromide (CTAB)-Modified Rice Husk in Aqueous Solution. Colloid J., 2022. 84, 196-207. https://doi.org/10.1134/S1061933X22020028
[62] Sudipta Saha, Chironjit Kumar Shaha, Subarna Karmaker and Tapan Kumar Saha*, First-Dose of Oxford–AstraZeneca COVID-19 Vaccination to Bangladeshi Residents: A Retrospective Cross-Sectional Study, Janangirnagar University J. Sci., 2020-21, 43, 49-62.
[61] Mahfuza Islam, Pollob Ghosh, Subarna Karmaker and Tapan Kumar Saha*, Kinetics, Equilibrium and Thermodynamic Investigation of New Coccine Adsorption onto Chitosan 10B in Aqueous Solution. Russ. J. Phys. Chem. B, 2021, (Suppl. 2), S189-S200, https://trebuchet.public.springernature.app/get_content/bc75a5b9-b891-444e-b5e1-269a4f726077
[60] Md. Mehedi Hasan, Pollob Ghosh, Subarna Karmaker and Tapan Kumar Saha*, Kinetics and Equilibrium Modelling for the Adsorption of Reactive Red 239 onto Used Tea Leaves in Aqueous Solution. J. Bangladesh Chem. Soc., 2021, 33, 40-50.
[59] Md. Salah Uddin, Soma Saha, Subarna Karmaker and Tapan Kumar Saha*, Adsorption of Cefixime Trihydrate onto Chitosan 10B from Aqueous Solution: Kinetics, Equilibrium and Thermodynamics Studies. Cellulose Chem. Technol., 2021, 7-8, 771-784. https://doi.org/10.35812/CelluloseChemTechnol.2021.55.64
[58] Tapan Kumar Saha*, Holm Frauendorf, and Franc Meyer*, Oxidative Degradation of Azo Dyes in Aqueous Solution by Water-Soluble Iron Porphyrin Catalyst. Eur. J. Inorg. Chem., 2021. https://doi.org/10.1002/ejic.202100373
[57] Bakul Akter, Ariful Islam Khan, Subarna Karmaker, Pollob Ghosh, Soma Saha, Shakil Ahmed Polash, Zinai Islam, Satya Ranjan Sarker, Md. Sharif Hossain, Hiroyuki Yasui, and Tapan Kumar Saha*, Chelation of Zinc(II) with Poly(γ-glutamic acid) in Aqueous Solution: Kinetics, Binding Consatnt and Its Antimicrobial Activity. Polym. Bull., 2021, 78, 1353-1377. https://doi.org/10.1007/s00289-020-03165-9
[56] Shaila Pervin, Chironjit Kumar Shaha, Subarna Karmaker and Tapan Kumar Saha*, Conjugation of Insulin-Mimetic [meso-Tetrakis(4-sulfonatophenyl)-porphyrinato] zinc(II) with Chitosan in Aqueous Solution: Kinetics, Equilibrium and Thermodynamics. Polym. Bull., 2021, 78, 4527-4550. https://doi.org/10.1007/s00289-020-03331-z
[55] Tapan Kumar Saha*, Raton Kumar Bishwas, Subarna Karmaker, and Zinia Islam, Adsorption Characteristics of Allura Red AC onto Sawdust and Hexadecylpyridinium Bromide-Treated Sawdust in Aqueous Solution. ACS Omega, 2020, 5, 13358-13374. https://doi.org/10.1021/acsomega.0c01493
[54] Tapan Kumar Saha*, Subarna Karmaker, Sanjay Debnath, and Md. Imran Ali Biswas, Solar Light Induced Glass-Supported Zinc Oxide Catalyzed Degradation of Allura Red AC in Aqueous Solution. Russ. J. Phys. Chem. A, 2020, 94, 2723-2732. https://doi.org/10.1134/S0036024420130233
[53] Nikhil C. Bhoumik, Tapan Kumar Saha, Shishir Ghosh, Vladimir N. Nesterov, Michael G. Richmond and Shariff E. Kabir, Facile Os-Os bond cleavage in the reactions of [Os3(CO)10(NCMe)2] and [Os3(CO)10(μ-H)2 ] with tetramethylthiuram disulphide (tmtd): Syntheses and crystal structures of new polynuclearosmium carbonyl complexes containing a dimethyldithiocarbamate ligand(s). J. Organomet. Chem., 2020, 911, 121133. https://doi.org/10.1016/j.jorganchem.2020.121133
[52] Subarna Karmaker, Amlan Jyoti Nag, and Tapan Kumar Saha*, Adsorption of Reactive Blue 4 Dye onto Chitosan 10B in Aqueous Solution: Kinetic Modeling and Isotherm Analysis. Russ. J. Phys. Chem. A, 2020, 94, 2349-2359. https://doi.org/10.1134/S0036024420110126
[51] Subarna Karmaker, Amlan Jyoti Nag, and Tapan Kumar Saha*, Adsorption of Remazol Brilliant Violet onto Chitosan 10B in Aqueous Solution: Kinetics, Equilibrium and Thermodynamics Studies. Cellulose Chem. Technol., 2019, 53(3-4), 373-386. http://dx.doi.org/10.35812/CelluloseChemTechnol.2019.53.38
[50] Subarna Karmaker, Farin Sintaha and Tapan Kumar Saha*, Kinetics, Isotherm and Thermodynamic Studies of the Adsorption of Reactive Red 239 Dye from Aqueous Solution by Chitosan 8B. Adv. Biol. Chem., 2019, 09(01), 1-22. doi: 10.4236/abc.2019.91001
[49] Subarna Karmaker, Tapan Kumar Saha, and Yutaka Yoshikwa, Study on biological activity of naturally occurring biopolymer poly(y-glutamic acid). Janangirnagar University J. Sci., 2018, 41, 1-8.
[48] Subarna Karmaker, Umme Kulsum, Bristy Biswas, and Tapan Kumar Saha, Chelation of copper(II) by natural and edible biopolymer poly(γ-glutamic acid) in aqueous solution. Janangirnagar University J. Sci., 2017, 40, 1-14.
[47] Subir Chowdhury and Tapan Kumar Saha, Removal of reactive blue 4 (RB4) onto puffed rice in aqueous solution. Int. J. Adv. Res., 2016, 4(3), 927-934. https://www.journalijar.com/article/8584/removal-of-reactive-blue-4-(rb4)-onto-puffed-rice-in-aqueous-solution/
[46] Subir Chowdhury and Tapan Kumar Saha, Removal of reactive orange 13 (RO13) onto rice hush in aqueous solution. Int. J. Res., 2016, 3(5), 138-146. https://journals.pen2print.org/index.php/ijr/article/view/4149
[45] Subir Chowdhury and Tapan Kumar Saha, Adsorption of reactive blue 4 (RB4) onto rice husk in aqueous solution. Int. J. Sci. Eng. Res., 2016, 7(3), 7-12. https://www.ijser.org/researchpaper/Adsorption-of-Reactive-Blue-4--RB4--onto-Rice-Husk-in-Aqueous-Solution.pdf
[44] Subir Chowdhury and Tapan Kumar Saha, Removal of Amaranth (AR) Onto Puffed Rice In Aqueous Solution. International Journal of Advance Research, 2016, 4(3), 1-8. ISSN 2320-9186. http://www.ijoar.org/journals/IJOAR/papers/REMOVAL-OF-AMARANTH-AR-ONTO-PUFFED-RICE-IN-AQUEOUS-SOLUTION.pdf
[43] Subarna Karmaker, Tusher Sen and Tapan Kumar Saha*, Adsorption of Reactive Yellow 145 onto Chitosan in Aqueous Solution: Kinetic Modeling and Thermodynamic Analysis. Polym. Bull., 2015, 72, 1879-1897. https://doi.org/10.1007/s00289-015-1378-4
[42] Subarna Karmaker, Md. Naim Uddin, Hideki Ichikawa, Yoshinobu Fukumori, and Tapan Kumar Saha,* Adsorption of Reactive Orange 13 onto Jackfruit Seed Flakes in Aqueous Solution. J. Environ. Chem. Eng., 2015, 3, 583-592. https://doi.org/10.1016/j.jece.2014.09.010
[41] Tapan Kumar Saha and Subir Chowdhury, Adsorption of Reactive Orange 13 (RO13) onto Puffed Rice in Aqueous Solution, 2nd International Conference on Multidisciplinary Research & Practice, 2015, 3(1), 8-12. https://www.rsisinternational.org/2ICMRP2015/08-12.pdf
[40] Tapan Kumar Saha,* Subarna Karmaker and Md. Feroje Alam, Kinetics, mechanism and thermodynamics involved in sorption of meso-tetrakis(4-sulfonatophenyl)porphyrin onto chitosan in aqueous medium. J. Porphyrins Phthalocyanines. 2014, 18, 240-250. https://doi.org/10.1142/S1088424613501174
[39] Tapan Kumar Saha,* Md. Farhad Mahmud and Subarna Karmaker, Adsorption Behavior of [meso-Tetrakis(4-carboxylatophenyl)porphyrinato]oxovanadium(IV) tetrasodium in Aqueous Solution onto Chitosan. Polym. Bull., 2013, 70, 2047-2063. https://doi.org/10.1007/s00289-013-0974-4
[38] Umme Salma, Tapan Kumar Saha, Mahbub Kabir and Mhuhammad Muslin, A kinetics study on the degradation of reactive navy blue in aqueous medium by using fenton and photo-fenton processes. J. Bangladesh Chem. Soc., 2013, 26(1), 83-92.
[37] Tapan Kumar Saha,* Holm Frauendorf, Michael John, Sebastain Dechert and Franc Meyer,* Efficient oxidative degradation of azo dyes by a water-soluble manganese porphyrin catalyst, ChemCatChem, 2013, 5, 796-805. https://doi.org/10.1002/cctc.201200475
[36] Umme Salma, Mhuhammad Muslin, Tapan Kumar Saha and Mahbub Kabir, ZnO mediated degradation of reactive navy blue by visible light. Janangirnagar University J. Sci., 2012, 35(2), 59-70.
[35] Tapan Kumar Saha,* Md. Farhad Mahmud, Subarna Karmaker and Tusher Sen, Adsorption of [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV) (4–) onto chitosan in aqueous solution. Polym. Bull., 2012, 68, 1483-1500. https://doi.org/10.1007/s00289-011-0696-4
[34] Tapan Kumar Saha,* Yutaka Yoshikawa, Hirouki Yasui and Hiromu Sakurai, In vitro insulin-mimetic activity and in vivo metallokinetic feature of oxovanadium(IV)porphyrin complexes in healthy rats. J. Porphyrins Phthalocyanines. 2012, 16, 114-121. https://doi.org/10.1142/S1088424612004458
[33] Tapan Kumar Saha,* Nikhil Chandra Bhoumik, Subarna Karmaker, Mahmooda Ghani Ahmed, Hideki Ichikawa, and Yoshinobu Fukumori, Adsorption characteristics of reactive black 5 from aqueous solution onto chitosan. Clean: Soil, Air, Water 2011, 39(10), 984-993. https://doi.org/10.1002/clen.201000315
[32] Tapan Kumar Saha,* Sunanda Rani Barmon, Subarna Karmaker, and Mahbub Kabir, Spectrophotometric investigation of nickel(II)-ciprofloxacin complex in pure and mixed solvents, J. Bangladesh Chem. Soc., 2010, 23(1&2), 67-76.
[31] Tapan Kumar Saha,* Nikhil Chandra Bhoumik, Subarna Karmaker, Mahmooda Ghani Ahmed, Hideki Ichikawa, and Yoshinobu Fukumori, Adsorption of methyl orange onto chitosan from aqueous solution. J. Water Resource Prot., 2010, 2(10), 898-906. doi: 10.4236/jwarp.2010.210107
[27] Subarna Karmaker, Tapan Kumar Saha* and Hiromu Sakurai, Antidiabetic activity of the orally effective vanadyl-poly(-glutamic acid) complex in streptozotocin(STZ)-induced type 1 diabetic mice, J. Biomater. Appl., 2008, 22(5), 449-464. https://doi.org/10.1177%2F0885328207078067
[22] Subarna Karmaker, Tapan Kumar Saha,* and Hiromu Sakurai, Investigation of Cu(II)-poly(-glutamic acid) complex in aqueous solution and its insulin-mimetic activity. Macromol. Biosci., 2007, 7, 456-466. https://doi.org/10.1002/mabi.200600227
[19] Tapan Kumar Saha, Yutaka Yoshikawa, Hiroyuki Yasui and Hiromu Sakurai, Oxovanadium(IV)-porphyrin complex as a potent insulin-mimetic: treatment of experimental type 1 diabetic mice by [meso-tetrakis(4-sulfonatophenyl)-porphyrinato]oxovanadate(IV)(4–) complex. Bull. Chem. Soc. Jpn., 2006, 79(8), 1191-1200. (Awarded article) https://doi.org/10.1246/bcsj.79.1191
[17] Farida Akhtar, Tapan Kumar Saha, M. Anamul Hoque and Md. Abdullah Khan, The binding of ciprofloxacine hydrocloride with polyvinyl pyrrolidone: the effect of temperature and pH, J. Bangladesh Chem. Soc., 2006, 19, 1-7.
[15] Tapan Kumar Saha, Yutaka Yoshikawa,Yusuke Adachi and Hiromu Sakurai, Insulinomimetic activity of vanadyl-porphyrin complexes. Biomedical Research on Trace Elements, 2005, 16, 328-331. https://doi.org/10.11299/brte.16.328
[11] Tapan Kumar Saha,* Subarna Karmaker and Keietsu Tamagake, Studies on the mechanism of the reaction of tetrakis({1-methylpyridinium-4-yl}porphyrinato)iron(III) pentaperchlorate with hydrogen peroxide, J. Porphyrins Phthalocyanines. 2003, 7, 693-699. https://doi.org/10.1142/S1088424603000860
[29] Farida Akhtar, Md. Anamul Hoque, Tapan Kumar Saha and Mohammed Abdullah Khan, Spectroscopic study on the interaction of ciprofloxacin hydrochloride with bovine serum albumin: thermodynamics of the binding equilibria and effect of temperature, pH and urea on the binding process. J. Bangladesh Chem. Soc., 2009, 22(2), 79-87.
[28] Subarna Karmaker, Tapan Kumar Saha,* Yutaka Yoshikawa, and Hiromu Sakurai, A zinc(II)-poly(-glutamic acid) complex as an oral therapeutic for the treatment of type 2 diabetic KKAy mice. Macromol. Biosci., 2009, 9(3), 279-286. https://doi.org/10.1002/mabi.200800190
[26] Subarna Karmaker and Tapan Kumar Saha,* Chelation of vanadium(IV) by natural and edible biopolymer poly--glutamic acid in aqueous solution: Structure and binding constant of complex, Macromol. Biosci., 2008, 8, 171-176. https://doi.org/10.1002/mabi.200700121
[21] Tapan Kumar Saha, Yutaka Yoshikawa and Hiromu Sakurai, Improvement in hyperglycemia and metabolic syndromes by oral treatment with the insulin-mimetic oxovanadium(IV)-porphyrin complex [meso-tetrakis(4-sulfonatophenyl)-porphyrinato]oxovanadium(IV)(4–) in type 2 diabetic KKAy mice, J. Pharm. Pharmacol., 2007, 59(3), 437-444. https://doi.org/10.1211/jpp.59.3.0014
[18] Subarna Karmaker, Tapan Kumar Saha, Yutaka Yoshikawa, Hiroyuki Yasui, and Hiromu Sakurai, A novel drug delivery system for type 1 diabetes: insulin-mimetic vanadyl-poly(-glutamic acid) complex. J. Inorg. Biochem., 2006, 100, 1535-1546. https://doi.org/10.1016/j.jinorgbio.2006.05.005
[16] Subarna Karmaker, Tapan Kumar Saha, Mahmooda Ghani Ahmed, and Farida Akhtar, Spectrophotometric investigation of Fe(III)-O-acetylsalicylic acid complex in pure and mixed solvents. J. Bangladesh Chem. Soc., 2005, 18, 118-125.
[14] Tapan Kumar Saha, Yusuke Adachi, Yutaka Yoshikawa, Hiroyuki Yasui, and Hiromu Sakurai, A new type of orally active insulin-mimetic vanadyl-porphyrin complex: meso-tetrakis({4-sulfonatophenyl}porphyrinato)oxovanadium(IV). Chem. Lett., 2005, 34, 1350-1351. https://doi.org/10.1246/cl.2005.1350
[10] Tapan Kumar Saha,* Subarna Karmaker and Keietsu Tamagake, Kinetic simulation studies on the transient formation of the oxo-iron(IV) porphyrin radical cation during the reaction of iron(III) tetrakis-5,10,15,20-(N-methyl-4-pyridyl)porphyrin with hydrogen peroxide in aqueous solution, Luminescence, 2003, 18, 259-267. https://doi.org/10.1002/bio.736
[8] Tapan Kumar Saha,* Subarna Karmaker and Keietsu Tamagake, Transient formation of the oxo-iron(IV) porphyrin radical cation during the reaction of iron(III) tetrakis-5,10,15,20-(N-methyl-4-pyridyl)porphyrin with hydrogen peroxide in aqueous solution, Luminescence, 2003, 18, 162-172. https://doi.org/10.1002/bio.718.
[4] K. M. Idriss Ali, M. Azam Ali, Tapan Kumar Saha and Mubarak Ahmed Khan, Influence of codiluent on the properties of radiation-cured films, Polym.-Plast. Technol. Eng., 1995, 34, 825-844. https://doi.org/10.1080/03602559508012179.
[30] Subarna Karmaker, Tapan Kumar Saha,* Yutaka Yoshikawa, and Hiromu Sakurai, Vanadyl-poly(γ-glutamic acid) complexes as oral therapeutic agents for the treatment of type 1 like diabetic mice, Afr. J. Pharm. Pharmacol., 2010, 4(5), 235-243. https://doi.org/10.5897/AJPP.9000289
[25] Subarna Karmaker, Tapan Kumar Saha,* Yutaka Yoshikawa and Hiromu Sakurai, Amelioration of hyperglycemia and metabolic syndromes in type 2 diabetic KKAy mice by poly(-glutamic acid)oxovanadium(IV) complex. ChemMedChem, 2007, 2, 1607-1612. https://doi.org/10.1002/cmdc.200700132
[24] Debbie C. Crans, Alvin A. Holder, Tapan Kumar Saha, G. K. Surya Prakash, Muhammed Yousufuddin, Roman Kultyshev, Rehana Ismail, Myron F. Goodman, James Borden, and Jan Florián, Chelation of vanadium(V) by difluoromethylene bisphosphonate, a structural analog of pyrophosphate, Inorg. Chem., 2007, 46, 6723-6732. https://doi.org/10.1021/ic062484r
[23] Tapan Kumar Saha,* Yutaka Yoshikawa and Hiromu Sakurai, [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]zinc(II) complex as an oral therapeutic for the treatment of type 2 diabetic KKAy mice. ChemMedChem, 2007, 2, 218-225. https://doi.org/10.1002/cmdc.200600228
[20] Tapan Kumar Saha,* Hideki Ichikawa, and Yoshinobu Fukumori, Gadolinium diethylenetriaminopetaaceitic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy, Carbohydr. Res., 2006, 341, 2835-2841. https://doi.org/10.1016/j.carres.2006.09.016
[13] Tapan Kumar Saha,* Subarna Karmaker, Hideki Ichikawa and Yoshinobu Fukumori, Mechanisms and kinetics of trisodium 2-hydroxy-1,1′-azonaphthalene-3,4′,6 trisulfonate adsorption onto chitosan. J. Colloid Interface Sci., 2005, 286, 433-439. https://doi.org/10.1016/j.jcis.2005.01.037
[12] Subarana Karmaker, Tapan Kumar Saha, Mahmooda Ghani Ahmed and Farida Akhtar, The complexation reaction of salicylic acid with Fe(III) in pure and mixed solvents studied by spectrophotometric method. J. Bangladesh Chem. Soc., 2004, 17, 23-31.
[9] Subarna Karmaker, Tapan Kumar Saha, Mahmooda Ghani Ahmed and Farida Akhtar, Determination of the stability constants of iron(III) complex of 5-sulfosalicylic acid in pure and mixed solvents with spectrophotometric method, J. Bangladesh Chem. Soc., 2003, 16, 110-117.
[7] Tapan Kumar Saha,* Subarna Karmaker and Keietsu Tamagake, Formation of TMPyPFe(IV)=O during the oxidation of Fe(II)TMPyP by dissolved molecular oxygen in aqueous solution, J. Bangladesh Chem. Soc., 2002, 15, 141-154.
[6] H. Tokumitsu, H. Ichikawa, Tapan Kumar Saha, Y. Fukumori and L.H. Block, Design and preparation of gadolinium-loaded chitosan particles for cancer neutron capture therapy, S.T.P Pharma Sciences, 2000, 10, 39-49.
[5] Tapan Kumar Saha, K. Jono, H. Ichikawa, and Y. Fukumori, Preparation and evaluation of glutaraldehyde cross-linked chitosan microspheres as a gadolinium reservoir for neutron-capture therapy, Chem. Pharm. Bull., 1998, 46, 537-539. https://doi.org/10.1248/cpb.46.537.
[3] Tapan Kumar Saha, Mubarak Ahmed Khan, and K. M. Idriss Ali, Physical and Mechanical properties of ultra violet (UV) cured films, Radiat. Phys. Chem., 1994, 44, 409-414. https://doi.org/10.1016/0969-806X(94)90080-9
[2] Tapan Kumar Saha, Mahmooda Ghani Ahmed and Farida Akhtar, Proton-ligand and metal-ligand formation constant of amoxicillin, J. Bangladesh Chem. Soc., 1994, 7, 29-38.
[1] Tapan Kumar Saha, Mahmooda Ghani Ahmed and Farida Akhtar, Formation constant of proton-ampicillin and metal-ampicillin complexes, J. Bangladesh Chem. Soc., 1993, 6, 1-8.
PATENT
[1] Hiromu Sakurai, Yutaka Yoshikawa, Tapan Kumar Saha, Preparation of zinc-porphyrin complexes as oral therapeutic agents for type II diabetes, Jpn. Kokai Tokkyo Koho, (2007). 9pp. CODEN: JKXXAF JP 2007302614 A 20071122 (Patent written in Japanese).
[2] Hiromu Sakurai, Yutaka Yoshikawa, Subarna Karmaker, Tapan Kumar Saha, Tomomitsu Sewaki, Yasushi Osanai, Mie Iwamoto, Jae-Chul Choi, Chung Park, Moon-Hee Sung, Antidiabetic agent comprising anionic polyamino acid-metal complex, PCT Int. Appl., (2007), 28pp. CODEN: PIXXD2 WO 2007043606 A1 20070419
Academic Info
Institute: Institute of Inorganic Chemistry, Georg-August-University, Göttingen, Germany
Period: July to September 2019
Research on “Analysis of products obtained from oxidative degradation of azo dye amaranth by HPLC-UV-HRMS” was carried out with Renewed Research Stay Sponsored by the Alexander von Humboldt (AvH) Foundation
Institute: Institute of Inorganic Chemistry, Georg-August-University, Göttingen, Germany
Period: March to May 2010; October to December 2011; March to May 2012; January to February 2013
Research on “Peroxidase-like catalytic activity of metalloporphyrin complexes using the stopped-flow technique” was carried out with Georg Forster Experienced Research Fellowship (AvH Foundation).
Institute: Department of Chemistry, Colorado State University, Fort Collins, USA
Period: September 2006 to February 2007
Research on “Chelation of vanadium(V) by difluoromethylene bisphosphonate, a structural analog of pyrophosphate” was carried out as a Postdoctoral Researcher.
Institute: Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan
Period: September 2004 to August 2006
Postdoctoral research on “Insulin-mimetic vanadyl(IV) and zinc(II)porphyrin complexes: Structure-activity relationship” was carried out with the Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship.
Institute: Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
Period: 1997 to 2002
Doctor of Philosophy (Ph.D.) in Biopharmaceutical Science with Monbusho Scholarship from the Ministry of Education, Culture, Sports, Science and Technology, Japan; Supervisor: Prof. Dr. Keietsu Tamagake.
Thesis title: “Formation mechanism of high-valent oxo-iron porphyrins induced by the reduction/oxidation of iron(III)-porphyrin -Studies by stopped-flow techniques-”. While commonly proposed oxo-iron(IV) intermediates are characterized for several heme enzymes and their biomimetic counterparts using some of the simple iron porphyrins, many details have not yet been established because of their complex formation mechanisms. Recently, we have explored the formation mechanism of oxo-iron(IV) porphyrins in both the reduction-induced oxidation and the direct oxidation processes of Iron(III) tetrakis-5,10,15,20-(N-methyl-4-pyridyl)porphyrin, Fe(III)TMPyP, using double-mixing rapid-scan stopped-flow spectrophotometric and stopped-flow luminol chemiluminescence techniques. These techniques having higher sensitivity are very useful to analyze the initial mechanism of the reactions. Our systematic studies provided significant information about the formation mechanism of TMPyPFe(IV)=O that can be formed via (TMPyP).+Fe(IV)=O in both the reduction initiated oxidation of FeTMPyP and the direct oxidation of Fe(III)TMPyP with H2O2. The values of the kinetic parameters showed that the (TMPyP).+Fe(IV)=O is 100 times more reactive than the TMPyPFe(IV)=O. I hope that the mechanistic details of oxo-iron(IV) porphyrins developed in our study will provide a better understanding of structure-function relationships and will also lead to design of efficient metalloporphyrin complexes for various purposes.
Institute: Faculty of Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Kobe, Japan.
Period: April 1995 to March 1996
Research on “Gadolinium-loaded chitosan particles for cancer neutron capture therapy” was carried out with Visiting Research Fellowship.
Institute: Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh
Period: 1988 (Examination held in 1990-91)
Master of Science (MSc) in Chemistry with First Class securing the second position in order of merit
A thesis title “Formation Constants of Some Metal-Antibiotic Complexes” was submitted for the partial fulfillment of MSc. The works involved the measurement of proton-ligand formation constants of ligands ampicillin and amoxicillin and the metal-ligand formation constants of these ligands with transition metal ions such as Co(II), Ni(II), Fe(II), Cu(II), and Cr(III) in aqueous solution by the pH-titration method. The measurements were extended over different temperatures and ionic strengths. The thermodynamic parameters of metal-ligand reactions were calculated.
Institute: Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh
Period: 1984 to 1987 (Examination held in 1989)
Bachelor of Science BSc (Hons.) in Chemistry with First Class securing the first position in order of merit
Institute: Government Michael Modhushudon College, Jessore, Bangladesh
Period: 1984
Higher Secondary School Certificate (HSC) in Science with First Division
Institute: Raigram Banikanta High School, Raigram, Jhenaidah, Bangladesh
Period: 1982
Secondary School Certificate (SSC) in Science with First Division
Contact
Dr. Tapan Kumar Saha
Professor
Department of Chemistry
Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
Cell Phone: +880-1915653108
Work Phone: +880-2-224491045-51 (PABX) 1437
Email: tksaha_ju@juniv.edu
, tksaha_ju@yahoo.com
